教育经历：

2019年9月 - 2024年6月：哈尔滨工业大学，生物学，理学博士

2015年9月 - 2019年6月：哈尔滨工业大学，食品科学与工程（药物方向），工学学士

工作经历：

2024年7月 - 至今 华中师范大学，生命科学学院，讲师/师资博士后

主要研究领域：

利用冷冻电镜技术等结构生物学手段，结合生物化学方法，进行蛋白结构与功能研究。

（1）基因转录调控过程中重要蛋白的结构动态变化和分子机制探究。

（2）GPCR等膜蛋白受体结构及其信号转导机制探究。

承担科研项目：

1.国家自然科学基金面上项目，基于结构基础上的阳光视紫红质蛋白生理功能研究和光遗传学工具改造，2021.01-2024.12，参与。

代表性论文：

[1]Yu Qian, Zhengxiong Ma, Chunhong Liu, Xinzhi Li, Xinyan Zhu, Na Wang, Zhenmei Xu, Ruixue Xia, Jiale Liang, Yaning Duan, Han Yin, Yangjie Xiong, Anqi Zhang, Changyou Guo, Zheng Chen, Zhiwei Huang, Yuanzheng He*, Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling. Molecular Cell. 2022, 82(22):4340-4352.e6.

[2]Yu Qian#, Zhengxiong Ma#, Zhenmei Xu, Yaning Duan, Yangjie Xiong, Ruixue Xia, Xinyan Zhu, Zongwei Zhang, Xinyu Tian, Han Yin, Jian Liu, Jing Song, Yang Lu, Anqi Zhang, Changyou Guo, Lihua Jin, Woo Jae Kim, Jiyuan Ke, Fei Xu, Zhiwei Huang & Yuanzheng He*. Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation. Nature Communications. 2024, 15(1):7644.

[3]Xinyan Zhu, Yu Qian, Xiaowan Li, Zhenmei Xu, Ruixue Xia, Na Wang, Jiale Liang, Han Yin, Anqi Zhang, Changyou Guo, Guangfu Wang, Yuanzheng He*. Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nature Communications. 2022, 13(1):5513.

[4]Na Wang, Yu Qian, Ruixue Xia, Xinyan Zhu, Yangjie Xiong, Anqi Zhang, Changyou Guo, Yuanzheng He*, Structural basis of CD97 activation and G-protein coupling. Cell Chemical Biology. 2023, 30(11):1343-1353.e5.

[5]Zhenmei Xu#, Tatsuya Ikuta#, Kouki Kawakami, Ryoji Kise, Yu Qian, Ruixue Xia, Mingxia Sun, Anqi Zhang, Changyou Guo, Xuehui Cai, Zhiwei Huang, Asuka Inoue*, Yuanzheng He*. Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nature Chemical Biology. 2022, 18(3):281-288.

[6]Jiale Liang#, Asuka Inoue#, Tatsuya Ikuta, Ruixue Xia, Na Wang, Kouki Kawakami, Zhenmei Xu, Yu Qian, Xinyan Zhu, Anqi Zhang, Changyou Guo, Zhiwei Huang, Yuanzheng He*. Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation. Nature Communications. 2023, 14(1):1012.

[7]Yaning Duan#, Nancy C P Leon#, Jing Zhao#, Yu Zhang, Dat T Nguyen, Hoa T T Ha, Na Wang, Ruixue Xia, Zhenmei Xu, Zhengxiong Ma, Yu Qian, Han Yin, Xinyan Zhu, Anqi Zhang, Changyou Guo, Yu Xia, Long N Nguyen*, Yuanzheng He*. Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Research. 2023, 34(2):177-180.

[8]Yangjie Xiong#, Zhenmei Xu#, Xinzhi Li#, Yuqin Wang#, Jing Zhao#, Na Wang, Yaning Duan, Ruixue Xia, Zhengbin Han, Yu Qian, Jiale Liang, Anqi Zhang, Changyou Guo, Asuka Inoue, Yu Xia*, Zheng Chen*, Yuanzheng He*. Identification of oleic acid as an endogenous ligand of GPR3. Cell Research. 2024, 34(3):232-244.

[9]Ruixue Xia#, Shuang Shi#, Zhenmei Xu, Henry F Vischer, Albert D Windhorst, Yu Qian, Yaning Duan, Jiale Liang, Kai Chen, Anqi Zhang, Changyou Guo, Rob Leurs, Yuanzheng He*. Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor. Nature Communications. 2024, 15(1):2493.