姓名: 闵金荣
职称: 教授
研究领域: 结构生物学、化学生物学、表观遗传学、蛋白质翻译后修饰
联系方式: minjinrong(AT)ccnu.edu.cn
教育经历:
1986.09 – 1990.06 武汉理工大学，学士学位
1990.09 – 1993.03 武汉理工大学/中国科学院物理研究所，硕士学位
1993.03 – 1995.08 中国科学院物理研究所，博士学位
工作经历:
1995.12-1996.06 德国萨尔兰大学，博士后
1996.06-1997.08 美国佛罗里达州立大学，博士后
1997.08-1998.12 德国埃森大学，洪堡学者
1999.03-2000.03 欧洲癌症研究所，博士后
2000.03-2005.06 美国冷泉港实验室，博士后
2005.06-2022.11 加拿大多伦多大学结构基因组中心，课题组长
2007.07-2022.11 加拿大多伦多大学医学院生理学助理教授、副教授、教授
2006.01-2022.11 华中师范大学，生命科学学院，讲座教授
2022.12-至今 华中师范大学，生命科学学院，教授
代表性论文: (*: 通讯作者)
Peer-reviewed research articles
2021-至今
Liu Y*, Iqbal A, Li W, Zuyao Ni, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, et al, Min J*. A small molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 2022 Sep 16;13(1):5453.
Liu Y*, Yang X, Zhou M, Yang Y, Li F, Yan X, Zhang M, Wei Z, Qin S, Min J*. Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain. J Biol Chem. 2022, 298:101623
Wu Z, Chen S, Zhou M, Jia L, Li Z, Zhang X, Min J*, Liu K*. Family-wide Characterization of Methylated DNA Binding Ability of Arabidopsis MBDs. J Mol Biol. 2022, 434:167404
Sun ZW, Waybright JM, Beldar S, Chen L, Foley CA, Norris-Drouin JL, Lyu TJ, Dong A, Min J, Wang YP, James LI, Wang Y. Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons. Adv Sci. 2022, 4:e2104317
Dilworth D, Hanley RP, Ferreira de Freitas R, Allali-Hassani A, Zhou M, Mehta N, Marunde MR, Ackloo S, Carvalho Machado RA, Khalili Yazdi A, Owens DDG, Vu V, Nie DY, Alqazzaz M, Marcon E, Li F, Chau I, Bolotokova A, Qin S, Lei M, Liu Y, Szewczyk MM, Dong A, Kazemzadeh S, Abramyan T, Popova IK, Hall NW, Meiners MJ, Cheek MA, Gibson E, Kireev D, Greenblatt JF, Keogh MC, Min J, Brown PJ, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, James LI, Schapira M. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2022, 18:56-63
Chen S, Zhou M, Dong A, Loppnau P, Wang M, Min J*, Liu K*. Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status. J Biol Chem. 2021, 297:101351
Du D, Xu D, Zhu L, Stazi G, Zwergel C, Liu Y, Luo Z, Li Y, Zhang Y, Zhu K, Ding Y, Liu J, Fan S, Zhao K, Zhang N, Kong X, Jiang H, Chen K, Zhao K, Valente S, Min J*, Duan W*, Luo C*. Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J Med Chem. 2021, 64:8194-8207
Zhang M, Lei M, Qin S, Dong A, Yang A, Li Y, Loppnau P, Hughes TR, Min J*, Liu Y*. Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. Biochim Biophys Acta Gene Regul Mech. 2021, 1864:194688
Ferreira de Freitas R, Liu Y, Szewczyk MM, Mehta N, Li F, McLeod D, Zepeda-Velázquez C, Dilworth D, Hanley RP, Gibson E, Brown PJ, Al-Awar R, James LI, Arrowsmith CH, Barsyte-Lovejoy D, Min J, Vedadi M, Schapira M, Allali-Hassani A. Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. J Med Chem. 2021, 64:1584-1592
Yan X, Wang X, Li Y, Zhou M, Li Y, Song L, Mi W*, Min J* and Dong C*. Molecular basis for ubiquitin ligase CRL2FEM1C mediated recognition of C-degron. Nat Chem Biol. 2021, 17:263-271
2016-2020
Dong C, Nakagawa R, Oyama K, Yamamoto Y, Zhang W, Dong A, Li Y, Yoshimura Y, Kamiya H, Nakayama JI, Ueda J, Min J*. Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife. 2020, 9:e58675
Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S*, Wang Y*, Min J*. Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol. 2020, 27:827-838
Dong C, Chen SJ, Melnykov A, Weirich S, Sun K, Jeltsch A, Varshavsky A*, Min J*. Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Proc Natl Acad Sci USA. 2020, 117:14158-14167
Zhang H, Devoucoux M, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J*, Min J*. Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex. Cell Rep. 2020, 30:3996-4002.e4
Liu Y, Qin S, Chen TY, Lei M, Dhar SS, Ho JC, Dong A, Loppnau P, Li Y, Lee MG* and Min J*, Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Nat Commun. 2019, 10:36
Dong C, Zhang H, Li L, Tempel W, Loppnau P, Min J*. Molecular basis of GID4-mediated recognition of Pro/N-degrons for the Pro/N-end rule pathway. Nat Chem Biol. 2018, 14:466-473
Zhang H, Zhou B, Qin S, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min J*. Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. Genes Dev. 2018, 32:341-346
Jurkowska R, Qin S, Kungulovski G, Tempel W, Liu Y, Bashtrykov P, Stiefelmaier J, Jurkowski T, Kudithipudi S, Tamas R, Wu H, Dombrovski L, Loppnau P, Reinhardt R, Min J*, Jeltsch A*. H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1. Nat Commun. 2017, 8:2057
Zhang H, Liu K, Izumi N, Huang H, Ding D, Ni Z, Sidhu S, Chen C, Tomari Y*, and Min J*. Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Proc Natl Acad Sci USA. 2017, 114:12483-12488
Xu C, Ishikawa H, Izumikawa K, Li L, He H, Nobe Y, Yamauchi Y, Shahjee HM, Wu XH, Yu YT, Isobe T, Takahashi N, Min J*. Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev. 2016, 30:2376-2390
2011-2015
Dong C, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R*, Min J*. Structural basis for substrate recognition by the human N-terminal methyltransferase 1. Genes Dev. 2015, 29:2343-8
Xu C*, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C*, Min J*. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat Chem Biol. 2014, 10:927-9
Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J*, Greenblatt JF*. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat Struct Mol Biol. 2014, 21:686-695
Qin S, Liu Y, Tempel W, Eram MS, Bian C, Liu K, Senisterra G, Crombet L, Vedadi M, Min J*. Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nat Commun. 2014, 5:3952
Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J*, Kato Y*, Shi YG*. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell. 2012, 151:1200-13
Zheng W, Ibáñez G, Wu H, Blum G, Zeng H, Dong A, Li F, Hajian T, Hassani AA, Amaya MF, Siarheyeva A, Yu W, Brown PJ, Schapira M, Vedadi M, Min J*, Luo M*. Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J. Am. Chem. Soc. 2012,134:18004-18014
Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, Pawson T*, Yang XJ*, Min J*. Sequence-specific Recognition of a PxLPxI/L Motif by the Ankyrin-repeat Tumbler Lock. Sci Signal. 2012, 5:ra39
Bian C, Xu C, Ruan J, Lee KK, Burke TL, Tempel W, Barsyte D, Li J, Wu M, Zhou BO, Fleharty BE, Paulson A, Allali-Hassani A, Zhou JQ, Mer G, Grant PA, Workman JL*, Zang J*, Min J*. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J. 2011, 30:2829-42
Adams-Cioaba MA, Krupa JC, Xu C, Mort JS*, Min J*. Structural basis for the recognition and cleavage of histone H3 by cathepsin L. Nat Commun. 2011, 2:197
Xu C, Bian C, Lam R, Dong A, Min J*. The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain. Nat Commun. 2011, 2:227
2001-2010
Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS*, Wang H*, Min J*. Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc Natl Acad Sci USA. 2010, 107:19266-71
Liu K, Chen C, Guo Y, Lam R, Bian C, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T*, Min J*. Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci USA. 2010, 107: 18398-18403
Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J*. Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. Nucleic Acids Res. 2009, 37:2204-10
Min J*, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH. L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol. 2007, 14:1229-1230
Schuetz A, Allali-Hassani A, Martín F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J*. Structural basis for molecular recognition and presentation of histone H3 By WDR5. EMBO J. 2006, 25:4245-4252
Min J, Zhang Y, Xu RM. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 2003, 17:1823-8
Min J, Feng Q, Li Z, Zhang Y, Xu RM. Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Cell. 2003, 112:711-23
Min J, Zhang X, Cheng X, Grewal SI, Xu RM. Structure of the SET domain histone lysine methyltransferase Clr4. Nat Struct Biol. 2002, 9:828-832
Min J, Landry J, Sternglanz R, Xu RM. Crystal structure of a SIR2 homolog-NAD complex. Cell. 2001, 105:269-279
1994-2000
Min J, Benet-Buchholz J, Boese R. Ab initio structure determination of norbornene from powder diffraction data using molecular packing analysis method. Chem Commun. 1998,24:2751-2752
Min J, Liang JK, Wang C, Dong C, Rao GH. The crystal structure and superconductivity of (Pb0.5Cd0.5)(Sr0.9Ln0.1)2(Ln0.7Ce 0.3)2Cu2O9 (Ln=Pr, Sm, Eu, Gd and Dy). J Phys-Condens Mat. 1996, 8:2869-2879
Min J, Liang JK, Wang C, Wu F, Dong C, and Rao, G.H. Characterization Of A New Pb-Based 1222-Cuprate Pb(Sr1.2La0.8)Gd2Cu2O9.06. J Phys-Condens Mat. 1995, 7:L405-L410.
Min J, Liang JK, Jin H, Wang C, Chen H, Yu, YD, Dong, C, and Rao, GH. A New Family Of Pb-Based-1222 Cuprates Pb(Sr,La)2Ln2Cu2Oz (Ln=Gd, Dy, Eu, And Pr). Physica C. 1995, 249:196-201
Min J, Liang JK, Chen XL, Wang C, Rao GH, Wu, F, and Dong, C. Preferential Occupancy and Composition-driven C-axis Variation in (Pb0.5Cd0.5) (Sr,Y,Ca)3Cu2O7-δ. Phys Rev B. 1995, 51:9261-9270
Min J, Liang JK, Chen XL, Wang C, Dong, C, Yu, YD, Cheng, XR, and Rao, GH. Synthesis And Superconducting Properties Of (Pb0.5Cd0.5)Sr2(Y0.5Ca0.5)Cu2O7. Physica C. 1995, 245:281-286
Min J, Wang J, Chen LQ, Xue RJ, Cui WQ, and Liang, JK. The Effects Of Mixed Glass Formers On The Properties Of Noncrystalline Lithium Ion Conductors. Phys Status Solidi A. 1995, 148:383-388
Min J, Chen LQ, Wang J, Xue RJ, Cui WQ. Electronic Conductivity of LiMn2O4-B2O3 Glasses and LiMn2O4-B2O3-P2O5 Glasses. Phys Status Solidi A. 1994, 146:771-776
Min J, Liang JK, Chen XL, Wang C, Dong C, and Rao, GH. The Crystal Structure of (Pb0.5Cd0.5)Sr2(Y1-xCax)Cu2O7. Physica C. 1994, 230:389-396
Min J, Liang JK, Chen XL, Wang C, Dong C and Rao, GH. The Effects of Chemical Substitutions on the (Pb,Cd)-1212 Superconducting Cuprates. Physica C. 1994, 229:169-176
Invited reviews and Book chapters
Liu K, Shimbo T, Song X, Wade PA, Min J*. Proteins That Read DNA Methylation. In: DNA Methyltransferases - Role and Function, editors: Albert Jeltsch, Renata Z. Jurkowska. Adv Exp Med Biol. 2022;1389:269-293.
Min J* and Liu K*, Structures of epigenetic modulators in complex with nucleosome. Curr Opin Chem Biol. 2021, 63:105-114
Liu K* and Min J*, Structural basis for the recognition of unmethylated DNA, J Mol Biol. 2020, 432: 1674-1686
Wu B, Li L, Huang Y*, Ma J*, Min J*. Readers, writers and erasers of N6-methylated adenosine modification. Curr Opin Struct Biol. 2017, 47:67-76
Liu Y, Li L, Min J*. HDAC6 finally crystal clear. Nat Chem Biol. 2016, 12:660-661
Liu K, Liu Y, Lau JL, Min J*. Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation. Pharmacol Ther. 2015, 151:121-40
Qin S, Min J*. Structure and function of the nucleosome-binding PWWP domain. Trends Biochem Sci. 2014, 39:536-47
Liu Y, Liu K, Qin S, Xu C, Min J*. Epigenetic targets and drug discovery: part 1: histone methylation. Pharmacol Ther. 2014, 143:275-94
Xu C, Min J*. Structure and function of WD40 domain proteins. Protein & Cell. 2011, 2:202-14
Qin S, Li L, Min J*. The Chromodomain of Polycomb: Methylation Reader and Beyond. In: Polycomb Group Proteins (Vincenzo Pirrotta, editor(s), 1st Edition). Academic Press, 2017. P33-56
学术兼职：
2021 - 至今 BBA Gene Regulatory Mechanisms，Executive Editor
2019 - 至今 Biochemistry, Molecular Biology and Cell Biology, Heliyon，Section Editor
2017 – 2019 Heliyon, 编委会成员
2015 - 至今 Protein & Cell，编委会成员
2006 - 至今 包括Nature及其子刊在内的60多家科学期刊评审人
2006 - 至今 国内外十余个科学基金评审人
2006 - 至今 组织和主持多个国际学术会议
