教育经历:
2004年09月- 2009年06月 山东大学 博士
2000年09月- 2004年06月 安徽师范大学 学士
工作经历:
2012年07月- 至今 华中师范大学 副教授
2019年08月- 2020年01月 加州大学河滨分校 访问学者
2015年09月- 2016年10月 加州大学河滨分校 访问学者
2012年03月- 2012年09月 香港大学 研究助理
2009年07月- 2012年06月 华中师范大学 讲师
主要研究领域:
1. 昆虫内分泌与先天免疫的互作机制
2. 昆虫生殖的内分泌调控机制
3. 害虫的生物防治
承担科研项目:
1. 国家自然科学基金面上项目(31872301):模式识别蛋白介导20E信号调控棉铃虫血细胞包囊的分子机理,2019.01-2022.12,主持。
2. 国家自然科学基金青年项目(31101672):棉铃虫应答20E调控体液免疫相关分子的鉴定和功能研究,2012.01-2014.12,主持。
3. 湖北省青年科技晨光计划(鄂科协办[2018]79号):蚊虫生殖控制技术与策略,主持。
4. 湖北省自然科学基金面上项目(2016CFB560):C型凝集素在棉铃虫抵御中华卵索线虫感染过程中的功能研究,2016.01-2017.12,主持。
5. 湖北省自然科学基金面上项目(2010CDB01204):基于蜕皮激素对昆虫体液免疫的调控寻找杀虫新靶标,2010.01-2011.12,主持。
6. 中央高校基本科研业务费探索创新类(CCNU19TS026):β-integrin介导棉铃虫血细胞包囊的分子机理,2019.04-2020.04,主持。
7. 中央高校基本科研业务费探索创新类(CCNU14A02013):棉铃虫C型凝集素3基因表达调控的分子基础,2014.01-2015.12,主持。
8. 遗传调控与整合生物学湖北省重点实验室开放课题(GRIB201702):20-羟基蜕皮酮调控棉铃虫血细胞包囊的分子机理,2017.01-2018.12,主持。
9. 国家自然科学基金面上项目(31672352):Wolbachia对果蝇雄性生殖系统先天免疫的影响及其与生殖的关系,2017.01-2020.12,参加。
代表性论文:
1、Wang GJ, Wang WW, Liu Y, Chai LQ, Wang GX, Liu XS, Wang YF, Wang JL*. 2021. Steroid hormone 20-hydroxyecdysone promotes CTL1-mediated cellular immunity in Helicoverpa armigera. Insect Science. 28:1399-1413.
2、Wang W, Wang G, Zhuo X, Liu Y, Tang L, Liu X, Wang J*. 2020. C-type lectin-mediated microbial homeostasis is critical for Helicoverpa armigera larval growth and development. PLoS Pathogens. 16:e1008901.
3、Lin Z#, Wang JL#, Cheng Y, Wang JX, Zou Z*. 2020. Pattern recognition receptors from lepidopteran insects and their biological functions. Developmental and Comparative Immunology. 108:103688.
4、Wang GJ, Zhuo XR, Wang WW, Liu XS, Wang GX, Wang JL*. 2019. Molecular characterization of immune responses of Helicoverpa armigera to infection with the mermithid nematode Ovomermis sinensis. BMC Genomics. 20:161.
5、Zhuo XR, Chen L, Wang GJ, Liu XS, Wang YF, Liu K, Yu XQ, Wang JL*. 2018. 20-Hydroxyecdysone promotes release of GBP-binding protein from oenocytoids to suppress hemocytic encapsulation. Insect Biochemistry and Molecular Biology. 92:53-64. (受邀为ATLAS of Science撰写layman¢s summary:http://atlasofscience.org/ecdysone-induces-a-termination-of-encapsulation-via-gbp-gbpb-interaction/).
6、Wang P#, Zhuo XR#, Tang L, Liu XS, Wang YF, Wang GX, Yu XQ, Wang JL*. 2017. C-type lectin interacting with β-integrin enhances hemocytic encapsulation in the cotton bollworm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology. 86: 29-40.
7、Wang JL, Saha TT, Zhang Y, Zhang C, Raikhel AS*. 2017. Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito. Journal of Biological Chemistry. 292: 10306-10315.
8、Li J, Song CX, Li YP, Li L, Wei XH, Wang JL*, Liu XS*. 2015. Rab3 is involved in cellular immune responses of the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology, 50: 78-86.
9、Wang JL, Chen L, Tang L, Zhao HB, Liu XS*, Wang YF*. 2014. 20-hydroxyecdysone transcriptionally regulates humoral immunity in the fat body of Helicoverpa armigera. Insect Molecular Biology, 23: 842-856.
10、Liu C#, Wang JL#, Zheng Y, Xiong EJ, Li JJ, Yuan LL, Yu XQ, Wang YF*. 2014. Wolbachia-induced paternal defect in Drosophila is likely by interaction with the juvenile hormone pathway. Insect Biochemistry and Molecular Biology, 49: 49-58.
11、Wang JL*, Zhang Q, Tang L, Chen L, Liu XS, Wang YF*. 2014. Involvement of a pattern recognition receptor C-type lectin 7 in enhancing cellular encapsulation and melanization due to its carboxyl-terminal CRD domain in the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology, 44: 21-29.
12、Wang JL*, Liu XS, Zhang Q, Zhao HB, Wang YF*. 2012. Expression profiles of six novel C-type lectins in response to bacterial and 20E injection in the cotton bollworm (Helicoverpa armigera). Developmental and Comparative Immunology, 37: 221-232.
13、Zheng Y#, Wang JL#, Liu C, Wang CP, Walker T, Wang YF*. 2011. Differentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophila. BMC Genomics, 12:595.
14、Wang JL, Wang LF, Wang JX, Zhao XF*. 2010. The expression patterns of a eukaryotic initiation factor 3 subunit H in the silk glands in Bombyx mori. Archives of Insect Biochemistry and Physiology, 75: 1-12.
15、Wang JL, Zhang YP, Gu YY, Wang JX, Zhao XF*. 2009. Function of a TGF-β inducible nuclear protein in the silk gland in Bombyx mori. Insect Molecular Biology, 18: 243-251.
16、Wang JL, Wang JX, Zhao XF*. 2008. Molecular cloning and expression profiles of the acyl-CoA-binding protein gene from the cotton bollworm Helicoverpa armigera. Archives of Insect Biochemistry and Physiology, 68: 79-88.
17、Wang JL, Jiang XJ, Wang Q, Hou LJ, Xu DW, Wang JX, Zhao XF*. 2007. Identification and expression profile of a putative basement membrane protein gene in the midgut of Helicoverpa armigera. BMC Developmental Biology, 7:76.
社会兼职:
湖北省昆虫学会理事(2018.10-)
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英文版:
Resume:
Jul.2012 - present: Associate Professor, Central China Normal University, Wuhan, China
Aug.2019 - Jan.2020: Visiting Scholar, University of California, Riverside, California, USA
Sep.2015 - Oct.2016: Visiting Scholar, University of California, Riverside, California, USA
Mar.2012 - Sep.2012: Research Assistant, The University of Hong Kong, Hong Kong, China
Jul.2009 - Jun.2012: Assistant Professor, Central China Normal University, Wuhan, China
Sep.2004 - Jun.2009: Ph.D. in Biochemistry and Molecular Biology, Shandong University, Jinan, China
Sep. 2000 - Jun.2004: B. Sc. in Biology, Anhui Normal University, Wuhu, China.
Research Interestes:
1. Interaction mechanisms between endocrine and innate immunity
2. Endocrine regulation of insect reproduction
3. Biological control of insect pests
Research Grants:
1. National Natural Science Foundation of China (no.31872301, 2019.01-2022.12): Molecular mechanisms for 20E signal regulation of hemocytic encapsulation mediated by pattern recognition proteins in Helicoverpa armigera.
2. National Natural Science Foundation of China (no.31101672, 2012.1-2014.12): Identification and functional analyses of immune-related genes in response to 20E treatment in the cotton bollworm (Helicoverpa armigera).
3. Natural Science Foundation of Hubei Province (2016CFB560, 2016.01-2017.12): Functional analyses of Helicoverpa armigera C-type lectins involved in defending against parasitism by Ovomermis sinensis.
4. Natural Science Foundation of Hubei Province (2010CDB01204, 2010.01-2011.12): Searching novel targets of insecticide based on 20E regulation of insect humoral immunity.
Representative Peer-reviewed Publications:
1. Wang GJ, Wang WW, Liu Y, Chai LQ, Wang GX, Liu XS, Wang YF, Wang JL*. 2021. Steroid hormone 20-hydroxyecdysone promotes CTL1-mediated cellular immunity in Helicoverpa armigera. Insect Science. 28:1399-1413.
2. Wang W, Wang G, Zhuo X, Liu Y, Tang L, Liu X, Wang J*. 2020. C-type lectin-mediated microbial homeostasis is critical for Helicoverpa armigera larval growth and development. PLoS Pathogens. 16:e1008901.
3. Lin Z#, Wang JL#, Cheng Y, Wang JX, Zou Z*. 2020. Pattern recognition receptors from lepidopteran insects and their biological functions. Developmental and Comparative Immunology. 108:103688.
4. Wang GJ, Zhuo XR, Wang WW, Liu XS, Wang GX, Wang JL*. 2019. Molecular characterization of immune responses of Helicoverpa armigera to infection with the mermithid nematode Ovomermis sinensis. BMC Genomics. 20:161.
5. Zhuo XR, Chen L, Wang GJ, Liu XS, Wang YF, Liu K, Yu XQ, Wang JL*. 2018. 20-Hydroxyecdysone promotes release of GBP-binding protein from oenocytoids to suppress hemocytic encapsulation. Insect Biochemistry and Molecular Biology. 92:53-64.
(Invited to prepare a layman¢s summary for ATLAS of Science:http://atlasofscience.org/ecdysone-induces-a-termination-of-encapsulation-via-gbp-gbpb-interaction/).
6. Wang P#, Zhuo XR#, Tang L, Liu XS, Wang YF, Wang GX, Yu XQ, Wang JL*. 2017. C-type lectin interacting with β-integrin enhances hemocytic encapsulation in the cotton bollworm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology. 86: 29-40.
7. Wang JL, Saha TT, Zhang Y, Zhang C, Raikhel AS*. 2017. Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito. Journal of Biological Chemistry. 292: 10306-10315.
8. Li J, Song CX, Li YP, Li L, Wei XH, Wang JL*, Liu XS*. 2015. Rab3 is involved in cellular immune responses of the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology, 50: 78-86.
9. Wang JL, Chen L, Tang L, Zhao HB, Liu XS*, Wang YF*. 2014. 20-hydroxyecdysone transcriptionally regulates humoral immunity in the fat body of Helicoverpa armigera. Insect Molecular Biology, 23: 842-856.
10. Liu C#, Wang JL#, Zheng Y, Xiong EJ, Li JJ, Yuan LL, Yu XQ, Wang YF*. 2014. Wolbachia-induced paternal defect in Drosophila is likely by interaction with the juvenile hormone pathway. Insect Biochemistry and Molecular Biology, 49: 49-58.
11. Wang JL*, Zhang Q, Tang L, Chen L, Liu XS, Wang YF*. 2014. Involvement of a pattern recognition receptor C-type lectin 7 in enhancing cellular encapsulation and melanization due to its carboxyl-terminal CRD domain in the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology, 44: 21-29.
12. Wang JL*, Liu XS, Zhang Q, Zhao HB, Wang YF*. 2012. Expression profiles of six novel C-type lectins in response to bacterial and 20E injection in the cotton bollworm (Helicoverpa armigera). Developmental and Comparative Immunology, 37: 221-232.
13. Zheng Y#, Wang JL#, Liu C, Wang CP, Walker T, Wang YF*. 2011. Differentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophila. BMC Genomics, 12:595.
14. Wang JL, Wang LF, Wang JX, Zhao XF*. 2010. The expression patterns of a eukaryotic initiation factor 3 subunit H in the silk glands in Bombyx mori. Archives of Insect Biochemistry and Physiology, 75: 1-12.
15. Wang JL, Zhang YP, Gu YY, Wang JX, Zhao XF*. 2009. Function of a TGF-β inducible nuclear protein in the silk gland in Bombyx mori. Insect Molecular Biology, 18: 243-251.
16. Wang JL, Wang JX, Zhao XF*. 2008. Molecular cloning and expression profiles of the acyl-CoA-binding protein gene from the cotton bollworm Helicoverpa armigera. Archives of Insect Biochemistry and Physiology, 68: 79-88.
17. Wang JL, Jiang XJ, Wang Q, Hou LJ, Xu DW, Wang JX, Zhao XF*. 2007. Identification and expression profile of a putative basement membrane protein gene in the midgut of Helicoverpa armigera. BMC Developmental Biology, 7:76.