副教授

  • 姓名:廖晓梅
  • 职称:副教授
  • 研究领域:1.海马依赖性学习与机制的细胞分子机制的研究2. 蛋白质降解障碍在脑认知缺陷中的作用和机制研究
  • 联系方式:liaodebox(AT))mail.ccnu. edu.cn
  • 办公室地址:5329
  • 更多信息:

基本情况简介Personal data+):

中文(出生日期,学历,职务)1974.01.19, 博士,副教授

英文(学历,职务)PHD, Associate Professor

主要学术兼职Professional Activities+):

中文内容: 湖北省生理学会副理事长

英文内容: Vice chairman of Hubei Physiological society

主要研究领域Research Interests+):

中文内容:脑与认知

英文内容:Brain and Cognition

学习工作经历 Resume:(时间要倒序,中+

l 学习经历 **月至今:**院(系),获*学位

l 2002/092005/07, 华中科技大学同济医学院, 病理学与病理生理学, 博士

l 1999/092002/06, 华中科技大学同济医学院, 病理学与病理生理学, 硕士

l 工作经历

l 2008/06-至今,华中师范大学,生命科学学院,副教授

l 2005/07-2008/06,华中师范大学,生命科学学院,讲师

l 1997/07-1999/07,赤壁市人民医院,内科,住院医

l (英文简历内容)

l EDUCATION

l 2002/092005/07, Department of Pathophysiology, Tongji Medical College of Huazhong University of Science and Technology, Ph.D.

l 1999/092002/06, Department of Pathophysiology, Tongji Medical College of Huazhong University of Science and Technology, M.D.

l WORK EXPERIENCE

l 2005-present: Work in the Central China Normal University,Wuhan, China

l 1997-1999: Work in the Physician of the People’s hospital of Chibi, Hubei,China

l

l 承担科研项目情况Research Grants:(从最近的项目写起,中+英)

项目类别(编号):项目名称,起止时间,主持/参加

l 1. 湖北省自然科学基金面上项目(2016CFB561),HDAC6tau蛋白降解过程中的作用和机制研究,2016.01- 2017.123万元,主持;

l 2. 中央高校基本科研业务费基金项目,(CCNU15A02024):UCHL1对异常聚集tau蛋白经自噬途径降解作用的研究,2015.06-2017.068万元,主持;

l 3. 中央高校基本科研业务费基金项目,CCNU09B01009,奖惩刺激对学习与记忆的影响及其机制研究,2010/01-2011/1220万元,主持;

l 4. 国家自然科学基金青年项目,30700208,蛋白酶体活性抑制在神经原纤维缠结形成中的作用和机制研究,2008/012010/1216万元,主持;

l 5. 武汉市青年科技晨光计划,200850731362,基于蛋白酶体活性下降的阿尔茨海默病脑片模型的建立,2008/012010/125万元,主持;

l 6. 湖北省自然科学基金面上项目,2007ABA150,听中枢tau蛋白过度磷酸化对声信号加工的影响及其机制研究,2007/012008/124万元,主持。

 

GRANTS FUNDED

l 1. Natural Science Foundation of Hubei Privince(2016CFB561)Effects of HDAC6 on taudegradation and its underlying mechanisms, 2016.01- 2017.12, PI.

l 2. Fundamental Research Funds for the Central-affiliated Universities (CCNU15A02024): Effects of UCHL1 on aggregated tau degradation by autophagy pathway. 2015.06-2017.06, PI

l 3. Fundamental Research Funds for the Central-affiliated UniversitiesCCNU09B01009):Effects of reward and punishment on learning and memory and the underlying mechanisms. 2010.01-2011.12, PI.

l 4. National Natural Science Foundation of China (30700208): Effects of proteasome inhibition on the formation of neurofibrillary tangle, 2008.01- 2010.12PI.

l 5. Wuhan Chenguang Project for Youth Scholar (200850731362): The establishment of Alzheimers disease slice model based on the down-regulation of proteasome. 2008.01-2010.12, PI.

l 6. Natural Science Foundation of Hubei Privince(2007ABA150): Effect of tau hyperphosphorylation on acoustic signal processing and its underlying mechanisms, 2007.01-2009.12, PI.

 

代表性论文Selected Publications:(请将本人名字及期刊名称加粗,期刊斜体。另:中文的无需翻译)

l 1. Yu Quntao(#), Zhang Hongmao(#), Li Yuan, Liu Chao, Wang Shaohui(*), LiaoXiaome(*), UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment. Molecular Neurobiology, 2018, 55:3812–3821.

l 2. Cheng Liang(#), Wang Shaohui (#), Kang Peng, Liao Xiaomei (*), Long-Term Impairment of Sound Processing in the Auditory Midbrain by Daily Short-Term Exposure to Moderate Noise. Neural Plasticity, 2017, DOI: 10.1155/2017/3026749.

l 3. Xie Min(#), Li Yuan(#), Wang Shaohui(#), Yu Quntao, Meng Xin, Liao Xiaomei(*),The Involvement of NR2B and tau Protein in MG132-Induced CREB Dephosphorylation. Journal of Molecular Neuroscience, 2017, 62:154–162.

l 4. Wang shaohui(#), Zhang Pengyan(#), Liu Ruifang, Li Yuan, Liu Chao and Liao Xiaomei (*), DEHP Plasticizer Alters Synaptic Proteins Via Peroxidation, Toxicol. Res., 2017,6: 89-97.

l 5. Xie Min(#), Han Yun(#), Yu Quntao, Wang Xia, Wang Shaohui, Liao Xiaomei(*), UCH-L1 inhibition decreases the microtubule-binding function of tau protein, Journal of Alzheimer’s Disease , 2016,49:353 -363.

l 6. Cheng Liang(#), Wang Shaohui (#), Huang Yun, Liao Xiaomei (*), The hippocampus may be more susceptible to environmental noise than the auditory, Hearing Research, 2016 , 333: 93-97.

l 7. Tang Jiaqi(#), Yuan Ye(#),Wei Chenxi, Liao Xiaomei,Yuan Junlin,Nanberg Eewa, Zhang Yinping, Bornehag Carl-Gustaf(*), Yang Xu(*) , Neurobehavioral changes induced by di(2-ethylhexyl) phthalate and the protective effects of vitamin E in Kunming miceToxicology Research20154: 1006-1015.

l 8. Xie Min(#), Shi Ruihong(#), Pan Ying(#), Zeng Tao, Chen Qicai, Wang Shaohui, Liao Xiaomei(*), Proteasome inhibition induced downregulation of Akt/GSK-3β pathway contributes to abnormality of tau in hippocampal slice, Molecular Neurobiology, 2014, 50: 888-895.

l 9. Xie Min(#), Wang Shaohui(#), Lu Zhimin, Pan Ying, Chen Qicai, Liao Xiaomei(*), UCH-L1 inhibition involved in CREB dephosphorylation in hippocampal slices, Journal of Molecular Neuroscience , 2014,53: 59-68.

l 10. Cheng Liang(#), Wang Shaohui(#), Jia Nan, Xie Min, Liao Xiaomei(*), Environmental stimulation influence the cognition of developing mice by inducing changes in oxidative and apoptosis status, Brain & Development , 2014,36: 51-56.

l 11. Wang Shaohui (#), Liao XiaoMei, Liu Dan, Hu Juan, Yin Yangyang, Wang Jianzhi(*), Zhu Lingqiang(*), NGF promotes long-term memory formation by activating poly (ADP-ribose) polymerase-1, Neuropharmacology, 2012, 63: 1085- 1092.

l 12. Cheng Liang(#), Wang Shaohui(#), Chen Qicai, Liao Xiaomei(*), Moderate noise induced cognition impairment of mice and its underlying mechanisms, Physiology & Behavior, 2011, 104: 981-988.

l 13. 谢敏(#),陈其才,廖晓梅(*) 泛素C末端水解酶L1对神经元的保护作用, 生物化学与生物物理进展,2010371054-1058.

l 14. Ren Qingguo(#) , Liao Xiaomei(#) ,Wang Zefen, Qu Zhongshen, Wang Jianzhi(*), The involvement of glycogen synthase kinase-3 and protein phosphatase- 2A in lactacystin-induced tau accumulationFEBS Letters, 2006580: 2503- 2511.

l 15. Ren Qingguo(#), Liao Xiaomei(#), Chen Xiaoqian, Liu GongpPing, Wang Jianzhi(*)Effects of tau phosphorylation on proteasome activity, FEBS Letters, 2007, 581: 1521- 1528.