教授

  • 姓名:刘绪生
  • 职称:教授
  • 研究领域:昆虫病原真菌的致病机理
  • 联系方式:xsliu(AT) mail.ccnu.edu.cn
  • 办公室地址:5号楼308室
  • 更多信息:

教育经历:

20019- 20046 中国科学院动物研究所  博士

19989- 20016 南京农业大学植物保护学院 硕士

19949- 19986 湖北农学院农学系  学士

 

工作经历:

20157- 至今  华中师范大学生命科学学院 教授

20124- 20134 美国威斯康辛大学麦迪逊分校 访问学者

20061- 20156 华中师范大学生命科学学院 副教授

20047- 200512 华中师范大学生命科学学院 讲师

 

主要研究领域:

1、昆虫病原真菌的致病机理:以在害虫生物防治中具有重要应用价值的绿僵菌和球孢白僵菌为主要的研究对象,鉴定这些昆虫病原真菌在寄生过程中分泌到宿主昆虫血淋巴中的免疫抑制(或逃避)蛋白及次生代谢物,揭示这些毒力因子克服昆虫的免疫系统并最终杀死宿主昆虫的分子机理。

2、昆虫病原真菌的遗传改良:将外源毒力基因导入昆虫病原真菌的基因组中,使这些毒力基因在真菌中高表达,增加真菌的毒力,加快昆虫病原真菌杀死害虫的速度,提高昆虫病原真菌作为生物杀虫剂的防治效果。

承担科研项目:

1、国家自然科学基金面上项目:莱氏绿僵菌逃避宿主昆虫免疫反应的分子机理(32172489)2022.1-2025.12,主持。

2、国家自然科学基金面上项目:莱氏野村菌抑制宿主昆虫免疫反应分子机理的研究(31772220)2018.1-2021.12,主持。

3教育部留学回国人员科研启动基金项目:Ha-DFP1基因在棉铃虫先天性免疫中作用的研究(2014-1685-48)2015.1-2016.12,主持。

4国家自然科学基金青年项目:棉铃虫血细胞包囊作用相关基因的鉴定及功能研究(31000982)2011.1-2013.12,主持。

5武汉市晨光计划:武汉市蔬菜地索科线虫资源及应用潜能评价(200750731284)2007.1-2009.12,主持。

6、湖北省自然科学基金:中华卵索线虫DMRT1基因的克隆及功能分析(2005ABA130)2005.1-2006.12,主持。

 

代表性论文:

1. Liu ZC, Zhou L, Wang JL, Liu XS*. Expression of a phenoloxidase cascade inhibitor enhances the virulence of the fungus Beauveria bassiana against the insect Helicoverpa armigera. Developmental and Comparative Immunology, 2021, 117: 103986.

2. Li L, Zhong K, Wang JL, Liu XS*. Mechanism of Metarhizium rileyi evading cellular immune responses in Helicoverpa armigera. Archives of Insect Biochemistry and Physiology, 2021, 106(3): e21769.

3. Wang W, Wang G, Zhuo X, Liu Y, Tang L, Liu X, Wang J*. C-type lectin-mediated microbial homeostasis is critical for Helicoverpa armigera larval growth and development. PLoS Pathogens, 2020, 16: e1008901.

4. Chowdhury M, Li CF, He Z, Lu Y, Liu XS, Wang YF, Ip YT, Strand MR, Yu XQ*. Toll family members bind multiple Spätzle proteins and activate antimicrobial peptide gene expression in Drosophila. Journal of Biological Chemistry, 2019, 294: 10172–10181.

5. Chowdhury M, Zhang J, Xu XX, He Z, Lu Y, Liu XS, Wang YF, Yu XQ*. An in vitro study of NF-κB factors cooperatively in regulation of Drosophila melanogaster antimicrobial peptide genes. Developmental and Comparative Immunology, 2019, 95: 50–58.

6. Wen Y, He Z, Xu T, Jiao Y, Liu X, Wang YF, Yu XQ*. Ingestion of killed bacteria activates antimicrobial peptide genes in Drosophila melanogaster and protects flies from septic infection. Developmental and Comparative Immunology, 2019, 95: 10–18.

7. Wang GJ, Zhuo XR, Wang WW, Liu XS, Wang GX, Wang JL*. Molecular characterization of immune responses of Helicoverpa armigera to infection with the mermithid nematode Ovomermis sinensis. BMC Genomics, 2019, 20: 161.

8. Zhuo XR, Chen L, Wang GJ, Liu XS, Wang YF, Liu K, Yu XQ, Wang JL*. 20-Hydroxyecdysone promotes release of GBP-binding protein from oenocytoids to suppress hemocytic encapsulation. Insect Biochemistry and Molecular Biology, 2018, 92: 53–64.

9. Hu QQ, Wei XH, Li YP, Wang JL, Liu XS*. Identification and characterization of a gene involved in the encapsulation response of Helicoverpa armigera haemocytes. Insect Molecular Biology, 2017, 26(6): 752–762.

10. Zhong K, Liu ZC, Wang JL, Liu XS*. The entomopathogenic fungus Nomuraea rileyi impairs cellular immunity of its host Helicoverpa armigera. Archives of Insect Biochemistry and Physiology, 2017, 96(1): e21402.

11. Wang P, Zhuo XR, Tang L, Liu XS, Wang YF, Wang GX, Yu XQ, Wang JL*. C-type lectin interacting with β-integrin enhances hemocytic encapsulation in the cotton bollworm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology, 2017, 86: 29–40.

12. Liu KY, Xia YQ, Zhou J, Chen ZW, Lu D, Zhang NZ, Liu XS, Ai H*. Molecular characterization of autophagy-related gene 5 from Spodoptera exigua and expression analysis under various stress conditions. Archives of Insect Biochemistry and Physiology, 2016, 92(4): 225–241.

13. Li YP, Xiao M, Li L, Song CX, Wang JL, Liu XS*. Molecular characterization of a peptidoglycan recognition protein from the cotton bollworm, Helicoverpa armigera and its role in the prophenoloxidase activation pathway. Molecular Immunology, 2015, 65(1): 123–132.

14. Li J, Song CX, Li YP, Li L, Wei XH, Wang JL*, Liu XS*. Rab3 is involved in cellular immune responses of the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology, 2015, 50(2): 78–86.

15. Qiao C, Li J, Wei XH, Wang JL, Wang YF, Liu XS*. SRP gene is required for Helicoverpa armigera prophenoloxidase activation and nodulation response. Developmental and Comparative Immunology, 2014, 44(1): 94–99.

16. Wang JL*, Zhang Q, Tang L, Chen L, Liu XS, Wang YF*. Involvement of a pattern recognition receptor C-type lectin 7 in enhancing cellular encapsulation and melanization due to its carboxyl-terminal CRD domain in the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology, 2014, 44(1): 21–29.

17. Li L, Li YP, Song CX, Xiao M, Wang JL, Liu XS*. Identification and functional characterization of a peptidoglycan recognition protein from the cotton bollworm, Helicoverpa armigera. Archives of Insect Biochemistry and Physiology, 2014, 86(4): 240–258.

18. Wang JL, Chen L, Tang L, Zhao HB, Liu XS*, Wang YF*. 20-hydroxyecdysone transcriptionally regulates humoral immunity in the fat body of Helicoverpa armigera. Insect Molecular Biology, 2014, 23(6): 842–856.

19. Yang DQ, Su ZL, Qiao C, Zhang Z, Wang JL, Li F, Liu XS*. Identification and characterization of two peptidoglycan recognition proteins with zinc-dependent antibacterial activity from the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology, 2013, 39(4): 343–351.

20. Xia XF, Zheng JJ, Shao GM, Wang JL, Liu XS, Wang YF*. Cloning and functional analysis of glutathione peroxidase gene in red swamp crayfish Procambarus clarkia. Fish & Shellfish Immunology, 2013, 34: 1587–1595.

21. Wang JL*, Liu XS, Zhang Q, Zhao HB, Wang YF*. Expression profiles of six novel C-type lectins in response to bacterial and 20E injection in the cotton bollworm (Helicoverpa armigera). Developmental and Comparative Immunology, 2012, 37(2): 221–232.

22. Li Q, Sun Y, Wang G, Liu X*. Effects of the mermithid nematode Ovomermis sinensis on the hemocytes of its host Helicoverpa armigera. Journal of Insect Physiology, 2009, 55(1): 47–50.