教授

  • 姓名:李睿
  • 职称:教授
  • 研究领域:环境相关疾病导向性的分子生物学/分子毒理学研究
  • 联系方式:ruili(AT) ccnu.edu.cn
  • 办公室地址:5号楼319室
  • 更多信息:

育经历:

新加坡南洋理工大学 生物工程博士学位

华中师范大学 植物学硕士学位

华中师范大学 生物学硕士学位

 

工作经历:

华中师范大学生命科学学院 助教、讲师、副教授、教授

美国加利福尼亚大学伯克利分校 访问学者

美国西弗吉尼亚大学 博士后

 

荣誉或奖励(包括各类人才计划

综合类:

2020-2022年度  华中师范大学三育人先进个人

2017   华中师范大学优秀共产党员

20122014  华中师范大学优秀实习指导教师

科研类:

2022  湖北省自然科学奖三等奖

2017  中华预防医学会科学技术奖二等奖

教学类:

2022 省级线上线下混合式一流本科课程(《铸就健与美的能量平衡》)

2022 全国高校教师教学创新大赛国赛三等奖暨省赛一等奖(《分子生物学》)

2020 国家级线下一流本科课程(《分子生物学》)

2020 华中师范大学课程思政优秀教师

2020 华中师范大学课程思政示范课程(《分子生物学》)

2019 全国高校生命科学类微课教学比赛三等奖、教学风采奖

2017 华中师范大学本科教学创新奖一等奖第一名

2014 华中师范大学年度教学工作优秀二等奖

2013 首届全国高校微课教学比赛教育部优秀奖暨湖北省一等奖

指导学生获奖:

2022 全国大学生生命科学竞赛国赛三等奖暨省赛一等奖

2020 全国大学生生命科学竞赛国赛一等奖暨省赛一等奖

2017 指导研究生获中国环境科学学会学术年会优秀论文二等奖

2017 指导研究生获中国环境科学学会室内环境与健康分会学术年会优秀论文奖

2014  指导本科生完成科研论文并获湖北省大学生优秀科研成果二等奖


承担科研项目:

1.国家自然科学基金面上项目(42077403):围产期PM2.5暴露致幼鼠自闭症样行为发生机制的研究,2021.01-2024.12,主持(57万元)

2.中央高校基本科研业务费重大项目(CCNU18JCXK07):环境毒理系统生物学研究,2018.06-2020.12,主持(60万元)

3.中央高校基本科研业务探索项目(CCNU19TS066),PM2.5和甲醛复合暴露致小鼠造血毒性及其分子机制的研究,2019.01-2020.12,主持(15万元)

4.科技部十三五重点研发计划项目(2017YFC0702701):建筑室内主要空气污染物清单及其健康影响机理研究(子课题),2017.07-2020.12,主持(80万元)

5.国家自然科学基金面上项目(21577045):PM2.5和甲醛复合暴露致小鼠哮喘样病变分子机制的研究,2016.01-2019.12,骨干(68万元)

6.中央高校基本科研业务费项目(CCNU15A02028):不同维度对于纳米氧化钨致小鼠神经毒性的影响研究,2015.01-2016.12,主持(8万元)

7.国家自然科学基金重点项目(51136002):室内半挥发性有机物污染控制中的关键工程热物理问题研究,2012.01-2016.12,骨干(80万元)

8.教育部直属高校聘请外国文教专家计划-学校特色项目(TS2012HZSF042):环境健康学科平台建设,2012.01-2015.12,骨干(60万元)

9.国家自然科学基金青年基金项目(21103059):形貌效应对纳米氧化钨-菌紫质复合体光电响应的影响与调控机制,2012.01-2014.12,主持(26万元)

10.中央高校基本科研业务费项目(CCNU12A01006):形貌效应对纳米氧化钨-菌紫质复合体光电响应的影响与调控机制,2012.01-2013.12,主持(5万元)

 

 

代表性论文:

1. Xianxian Lu, Cunyi Gong, Ke Lv, Lifang Zheng, Beibei Li, Yuanteng Zhao, Haonan Lu, Tingting Wei, Jiawei Huang, Rui Li*. Impacts of combined exposure to formaldehyde and PM2.5 at ambient concentrations on airway inflammation in mice[J]. Environmental Pollution, 2022.

2. Yao Li, Yun Zhao, Yu Lu, Xianxian Lu, Yingdan Hu, Qiulin Li, Menglei Shuai, Rui Li*. Autism spectrum disorder-like behavior induced in rat offspring by perinatal exposure to di-(2-ethylhexyl) phthalate[J]. Environmental Science and Pollution Research, 2022.

3. Lin Mao, Lifang Zheng, Huihui You, Muhammad Wajid Ullah, Haoyan Cheng, Qing Guo, Zhuge Xi, Rui Li*. A comparison of hepatotoxicity induced by different lengths of tungsten trioxide nanorods and the protective effects of melatonin in BALB/c mice[J]. Environmental Science and Pollution Research, 2021.

4. Yun Zhao, Laura C Magaña, Haiyan Cui, Jiawei Huang, Cliona M McHale, Xu Yang, Mark R Looney, Rui Li*, Luoping Zhang*. Formaldehyde-induced hematopoietic stem and progenitor cell toxicity in mouse lung and nose[J]. Archives of Toxicology, 2021.

5. Jing Ge, Honglian Yang, Xianxian Lu, Shenqi Wang, Yun Zhao, Jiawei Huang, Zhuge Xi, Luoping Zhang, Rui Li*. Combined exposure to formaldehyde and PM2.5: Hematopoietic toxicity and molecular mechanism in mice[J]. Environment International, 2020.

6. Haiyan Cui, Jiawei Huang, Manman Lu, Qian Zhang, Wei Qin, Yun Zhao, Xianxian Lu, Jiting Zhang, Zhuge Xi, Rui Li*. Antagonistic effect of vitamin E on nAl2O3-induced exacerbation of Th2 and Th17-mediated allergic asthma via oxidative stress[J]. Environmental Pollution, 2019.

7. Yun Zhao, Jing Ge, Xiaoxiao Li, Qing Guo, Yuqing Zhu, Jing Song, Luoping Zhang, Shumao Ding, Xu Yang, Rui Li*. Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of KATP, BKCa and L-type Ca2+ channels[J]. Toxicology Letters, 2019.

8. Xu Zhang, Yun Zhao, Jing Song, Xu Yang, Junfeng Zhang, Yinpin Zhang*, Rui Li*. Differential health effects of constant versus intermittent exposure to formaldehyde in mice: implications for building ventilation strategies[J]. Environmental Science & Technology, 2018.

9. Jiawei Huang, Yu Lu, Binyang Zhang, Shaoping Yang, Qian Zhang, Haiyan Cui, Xianxian Lu, Yun Zhao, Xu Yang, Rui Li*. Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde[J]. Toxicology, 2018.

10. Qing Guo, Huihui You, Xu Yang, Bencheng Lin, Zhu ZH, Zhisong Lu, Xiaoxiao Li, Yun Zhao, Lin Mao, Shiping Shen, Haoyan Cheng, Iiting Zhang, Lingfu Deng, Jianhua Fan, Zhuge Xi*, Rui Li*, Changming Li. Functional single-walled carbon nanotubes 'CAR' for targeting dopamine delivery into the brain of parkinsonian mice[J]. Nanoscale, 2017.

11. Jing Song, Jun Kang, Bencheng Lin, Jinquan Li, Yuqing Zhu, Junting Du, Xu Yang, Zhuge Xi*, Rui Li*. Mediating role of TRPV1 ion channels in the co-exposure to PM2.5 and formaldehyde of Balb/c mice asthma model[J]. Scientific Reports, 2017.

12. Shuai Shang, Jinquan Li, Yun Zhao, Zhuge Xi, Zhisong Lu, Baizhan Li, Xu Yang*, Rui Li*. Oxidized graphene-aggravated allergic asthma is antagonized by antioxidant vitamin E in Balb/c mice[J]. Environmental Science and Pollution Research, 2017.

13. Huihui You#, Rui Li#, Chenxi Wei, Shaohui Chen, Lin Mao, Zhenye Zhang, Xu Yang*. Thymic stromal lymphopoietin neutralization inhibits the immune adjuvant effect of di-(2-ethylhexyl) phthalate in Balb/c mouse asthma model[J]. Plos One, 2016.

14. Haoyan Cheng, Lin Mao, Xing Xu, Yan Zeng, Danni Lan, Hao Hu, Xu Wu, Huihui You, Xu Yang, Rui Li*, Zhihong Zhu*. The bifunctional regulation of interconnected Zn-incorporated ZrO2 nanoarrays in antibiosis and osteogenesis[J]. Biomaterials Science, 2015.

15. Haoyan Cheng, Lin Mao, Lele Wang, Hao Hu, Yangyang Chen, Zheni Gong, Chengjun Wang, Jisheng Chen, Rui Li*, Zhihong Zhu*. Bidirectional regulation of zinc embedded titania nanorods: antibiosis and osteoblastic cell growth[J]. RSC Advances, 2015.

16. Xudong Liu, Yuchao Zhang, Jinquan Li, Dong Wang, Yang Wu, Yan Li, Zhisong Lu, Samuel CT Yu, Rui Li*, Xu Yang*. Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid[J]. International Journal of Nanomedicine, 2014.

17. Huihui You, Shaohui Chen, Lin Mao, Bing Li, Ye Yuan, Rui Li*, Xu Yang*. The adjuvant effect induced by di-(2-ethylhexyl) phthalate (DEHP) is mediated through oxidative stress in a mouse model of asthma[J]. Food and Chemical Toxicology, 2014.

18. Chenjuan Ke, Yahui He, Hongwu He, Xu Yang, Rui Li*, Junlin Yuan*. A new spectrophotometric assay for measuring pyruvate dehydrogenase complex activity: a comparative evaluation[J]. Analytical Methods, 2014.

19. Huanan Wen, Jiaxin Zhong, Bei Shen, Tao Gan, Chao Fu, Zhihong Zhu, Rui Li*, Xu Yang*. Comparative study of the cytotoxicity of the nanosized and microsized tellurium powders on HeLa cells[J]. Frontiers in Biology, 2013.

20. Na Ren#, Rui Li#, Limei Chen, Guancong Wang, Duo Liu, Yingjun Wang, Lin Zheng, Wei Tang, Xiaoqiang Yu, Huaidong Jiang, Hong Liu*, Nianqiang Wu. In situ construction of a titanate-silver nanoparticle-titanate sandwich nanostructure on a metallic titanium surface for bacteriostatic and biocompatible implants[J]. Journal of Materials Chemistry, 2012.

21. Rui Li, Fengping Hu, Qiaoliang Bao, Shujuan Bao, Yan Qiao, Shucong Yu, Jun Guo, Chang Ming Li*. Enhancement of photoelectric response of bacteriorhodopsin by multilayered WO3•H2O nanocrystals/PVA membrane[J]. Chemical Communications, 2010.

22. Rui Li, Xiaoqiang Cui, Weihua Hu, Zhisong Lu, Chang Ming Li*. Fabrication of oriented Poly-L-lysine/bacteriorhodopsin-embedded purple membrane multilayer structure for enhanced photoelectric response[J]. Journal of Colloid and Interface Science, 2010.

23. Rui Li, Ye Gan, Qunliang Song, Zhihong Zhu, Jingsheng Shi, Hongbing Yang, Wei Wang, Peng Chen, Chang Ming Li*. Bidirectional mediation of TiO2 nanowires field effect transistor by dipole moment from purple membrane[J]. Nanoscale, 2010.

24. Biran Zhu, Lei Lei, Kaiyu Fu, Songlin Zhao, Jianghuan Hua, Lihua Yang, Jian Han*, Rui Li, Bingsheng Zhou. Neurotoxicity of tetrabromobisphenol A and SiO2 nanoparticle co-exposure in zebrafish and barrier function of the embryonic chorion[J]. Science of the Total Environment, 2022.

25. Wei Niu, Wanzhou Wang, Chen Huang, Zhihong Zhang, Le Ma, Rui Li, John Cherrie, Mark R. Miller, Miranda Loh, Jiahui Chen, Chun Lin, Shaowei Wu, Xinbiao Guo*, Furong Deng**. Cardiopulmonary benefits of respirator intervention against near road ambient particulate matters in healthy young adults: A randomized, blinded, crossover, multi-city study[J]. Chemosphere, 2022.

26. Junhui Guo, Yun Zhao, Xingpeng Jiang, Rui Li, Hao Xie, Leixin Ge, Bo Xie, Xu Yang*, Luoping Zhang*. Exposure to Formaldehyde Perturbs the Mouse Gut Microbiome[J]. Genes, 2018.

27. Shiping Shen, Jinquan Li, Huihui You, Zhuo Wu, Yang Wu, Yun Zhao, Yuqing Zhu, Qing Guo, Xiaoxiao Li, Rui Li, Ping Ma, Xu Yang*, Mingqing Chen*. Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin[J]. Food & Chemical Toxicology, 2016.

28. Meng Qi, Jiawei Huang, Hui Wei, Chaomin Cao, Shilun Feng, Qing Guo, Ewa M. Goldys, Rui Li, and Guozhen Liu*. Graphene oxide thin film with dual function integrated into a nanosandwich device for in vivo monitoring of interleukin-6[J]. Applied Materials and Interfaces, 2017.

29. Zhisong Lu, Jing Wang, Rui Li, Yan Qiao, Mengyao Zhou and Chang Ming Li*. Controllable stationary photocurrents genera ted from a bacteriorhodopsin/upconversion nanoparticle-based bionanosystem under NIR illumination[J]. Nanoscale, 2016.

30. Xudong Liu, Qing Guo, Yuchao Zhang, Jinquan Li, Rui Li, Yang Wu, Ping Ma, Xu Yang*. Intraperitoneal Injection Is Not a Suitable Administration Route for Single-Walled Carbon Nanotubes in Biomedical Applications[J]. Dose-Response, 2016.

31. Yuqing Zhu, Jinquan Li, Zhuo Wu, Yu Lu, Huihui You, Rui Li, Baizhan Li, Xu Yang* and Liju Duan*. Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice[J]. Toxicology Research, 2016.

32. Zhisong Lu, Jing Wang, Xiutao Xiang, Rui Li, Yan Qiao and Chang Ming Li*. Integration of bacteriorhodopsin with upconversion nanoparticles for NIR-triggered photoelectrical response[J]. Chemical Communications, 2015.

33. Jinquan Li, Li Li, Hanqing Chen, Qing Chang, Xudong Liu, Yang Wu, Chenxi Wei, Rui Li, Joseph K. C. Kwan, King Lun Yeung, Zhuge Xi, Zhisong Lu, Xu Yang*. Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma[J]. Scientific Reports, 2014.

34. Hongbo Xu, Ranfeng Ye, Shangyue Yang, Rui Li, Xu Yang*. Electrochemical DNA nano-biosensor for the detection of genotoxins in water samples[J]. Chinese Chemical Letters, 2014.

35. Yujie Ke, Xiaodan Qin, Yuchao Zhang, Hui Li, Rui Li, Junlin Yuan, Xu Yang, Shumao Ding*. In vitro study on cytotoxicity and intracellular formaldehyde concentration changes after exposure to formaldehyde and its derivatives[J]. Human & Experimental Toxicology, 2014.

36. Jinquan Li, Li Li, Xudong Liu, Rui Li, Xu Yang*. Single-wall carbon nanotube-induced airway hyperresponsiveness in rats and a postulated mechanism of action[J]. RSC Advances, 2013.

37. Yuchao Zhang, Xudong Liu, Cliona McHale, Rui Li, Luoping Zhang, Yang Wu, Xin Ye, Xu Yang, Shumao Ding*. Bone Marrow Injury Induced via Oxidative Stress in Mice by Inhalation Exposure to Formaldehyde[J]. PLos One, 2013.

 

学术兼职:

1. 中国环境科学学会室内环境与健康分会委员

2. 中国环境科学学会室内环境与健康分会公共卫生及毒理学组组长

3. 中国研究型医院学会环境医学分会常务理事

4. 湖北省预防医学会环境卫生专业委员会委员

5. 湖北省预防医学会过敏病专业委员会常务委员